Purpose: To determine if the changes in
lung ventilation using HP 3He-MRI can provide in vivo pulmonary physiology
highly relevant in defining CLAD phenotypes among lung transplant patients,
phenotypes which otherwise are undetectable by the usual PFT parameters such as
FEV1.
Methods: Thirteen lung transplant
recipients underwent ventilation HP 3He MR lung imaging and spirometry; the
latter was compared to baseline spirometry. Time from transplant was 2.5 ±2.5
yrs.
Results/ Conclusion: Declined lung
function after lung transplant correlated well with decreased ventilated lung
volume in the transplanted lung found with HP 3He MRI.
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