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Abstract #2137

Evaluation of ventilation changes in lung transplant recipients with hyperpolarized helium-3 MR imaging: Comparison with pulmonary function tests

Lucia Flors1, Talissa A Altes2, John P Mugler III1, G Wilson Miller1, Jaime F Mata1, Sarah K Kilbourne3, Hannah C Mannem3, Max M Weder3, and Yun M Shim3

1Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 2Department of Radiology, University of Missouri, 3Pulmonary and Critical Care Medicine, University of Virginia

Purpose: To determine if the changes in lung ventilation using HP 3He-MRI can provide in vivo pulmonary physiology highly relevant in defining CLAD phenotypes among lung transplant patients, phenotypes which otherwise are undetectable by the usual PFT parameters such as FEV1. Methods: Thirteen lung transplant recipients underwent ventilation HP 3He MR lung imaging and spirometry; the latter was compared to baseline spirometry. Time from transplant was 2.5 ±2.5 yrs. Results/ Conclusion: Declined lung function after lung transplant correlated well with decreased ventilated lung volume in the transplanted lung found with HP 3He MRI.

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