3D whole lung morphometry maps were acquired with 129Xe DW-MRI and compressed sensing. Prospective three-fold undersampled 3D 129Xe lung morphometry (LmD) maps were derived using the stretched exponential model (SEM) and compared with equivalent 3He datasets. Five healthy volunteers were imaged using a range of 129Xe diffusion times and the most agreeable 129Xe and 3He LmD results were obtained with a 129Xe diffusion time of 8.5 ms. These results indicate that the LmD values derived from the SEM are dependent on diffusion time and that 129Xe could present a clinically-viable alternative to 3He for whole lung morphometry mapping.
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