Meeting Banner
Abstract #2143

Dissolved phase Hyperpolarized Xenon-129 pulmonary imaging in the presence of gaseous Xenon signal

Jeff Kammerman1, Andrew Hahn1, Scott Haile Robertson2, Bastiaan Driehuys2, and Sean B Fain1

1Department of Medical Physics, University of Wisconsin at Madison, Madison, WI, United States, 2Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, NC, United States

Dissolved-phase hyperpolarized Xenon-129 imaging shows promise as a means to evaluate gas transfer from the airspaces of the lungs to parenchymal tissue and the blood stream. This typically requires selective excitation of dissolved-phase 129Xe, but its short T2* requires the use of short RF pulses. This reduces the achievable spectral selectivity and often leads to unwanted excitation of gas-phase Xenon. In this work, we present a method to selectively remove gas-phase contamination from dissolved-phase images. Our method is developed and validated with guidance from simulated data using a digital phantom and shown to be feasible in human subject scans.

This abstract and the presentation materials are available to members only; a login is required.

Join Here