Dissolved-phase hyperpolarized Xenon-129 imaging shows promise as a means to evaluate gas transfer from the airspaces of the lungs to parenchymal tissue and the blood stream. This typically requires selective excitation of dissolved-phase 129Xe, but its short T2* requires the use of short RF pulses. This reduces the achievable spectral selectivity and often leads to unwanted excitation of gas-phase Xenon. In this work, we present a method to selectively remove gas-phase contamination from dissolved-phase images. Our method is developed and validated with guidance from simulated data using a digital phantom and shown to be feasible in human subject scans.
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