Abstract #2142

Assessment of Repeatability of Disease Burden and ADC estimates in Malignant Pleural Mesothelioma using Diffusion Weighted Imaging

Lin Cheng¹, Matthew D. Blackledge¹, David J. Collins¹, Nina Tunariu^1,2, Matthew R. Orton¹, Martin O. Leach¹, and Dow-Mu Koh^1,2

¹Division of Radiotherapy and Imaging, Cancer Research UK Cancer Imaging Centre, Institute of Cancer Research, London, United Kingdom, ²Radiology, Royal Marsden Hospital, London, United Kingdom

We demonstrate the repeatability of tumour volume and apparent diffusion coefficient (ADC) estimates; obtained by combining 3D semi-automatic segmentation with a global ADC threshold using DW-MRI in malignant pleural mesothelioma. The results of our classification of solid tumour show excellent repeatability of mean and median ADC estimates and tumour volume. Our methodology provides a clinical tool for radiologists to evaluate tumour burden of MPM in a fast and highly repeatable way.

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