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Abstract #2142

Assessment of Repeatability of Disease Burden and ADC estimates in Malignant Pleural Mesothelioma using Diffusion Weighted Imaging

Lin Cheng1, Matthew D. Blackledge1, David J. Collins1, Nina Tunariu1,2, Matthew R. Orton1, Martin O. Leach1, and Dow-Mu Koh1,2

1Division of Radiotherapy and Imaging, Cancer Research UK Cancer Imaging Centre, Institute of Cancer Research, London, United Kingdom, 2Radiology, Royal Marsden Hospital, London, United Kingdom

We demonstrate the repeatability of tumour volume and apparent diffusion coefficient (ADC) estimates; obtained by combining 3D semi-automatic segmentation with a global ADC threshold using DW-MRI in malignant pleural mesothelioma. The results of our classification of solid tumour show excellent repeatability of mean and median ADC estimates and tumour volume. Our methodology provides a clinical tool for radiologists to evaluate tumour burden of MPM in a fast and highly repeatable way.

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