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Abstract #2141

Double tracer gas single breath washout (SBW) lung imaging with hyperpolarized Xe-129 and He-3

Felix C Horn 1, Guilhem J Collier1, Ho-Fung Chan1, Neil J Stewart1, Laurie Smith1, and Jim M Wild1,2

1Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2Insigneo Institute, University of Sheffield, Sheffield, United Kingdom

Single breath washout (SBW) is an emerging pulmonary function test due to its relative simplicity and speed. Most significant outcome parameter, phase III ‘alveolar’ slope (tracer gas decay during mid-exhalation) is sensitive to ventilation heterogeneity. In this work, a method is presented for SBW-imaging with two tracer gases with inherently different physical properties: hyperpolarized 129Xe and 3He. Findings in our study are in agreement with trends seen in SBW from pulmonary function lab: the heavier, less diffusive gas (129Xe) has a steeper phase III slope. This indicates increased regional ventilation heterogeneity due to a lesser degree of diffusional mixing.

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