Meeting Banner
Abstract #2140

Large-scale production of highly-polarized 129Xe

Graham Norquay1, Guilhem J Collier1, Madhwesha Rao1, Adam Maunder1, Oliver I Rodgers1, Neil J Stewart1, and Jim M Wild1

1Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom

Rapid production of large volumes of highly polarized 129Xe with continuous-flow spin-exchange optical pumping (SEOP) 129Xe polarizers is vital for high-throughput hyperpolarized (HP) 129Xe lung imaging and emergent clinical applications with dissolved 129Xe, e.g. brain perfusion. However, the production rate is limited by cell volume, previously between 300-1500 cm3. Here we present a custom-built 129Xe polarizer designed with a SEOP cell volume of 3500 cm3 which can produce 129Xe polarized to 35% at a Xe production rate of 1200 mL/hour, enabling high-SNR 129Xe lung imaging of naturally abundant Xe and high-SNR 129Xe brain imaging with isotopically-enriched Xe.

This abstract and the presentation materials are available to members only; a login is required.

Join Here