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Abstract #2145

Assessment of lung inflation state on the repeatability of hyperpolarized gas ventilation MRI

Paul John Clifford Hughes1, Laurie Smith1,2, Felix C. Horn1, Alberto Biancardi1, Neil J. Stewart1, Graham Norquay1, Guilhem J. Collier1, and Jim Wild1,3

1POLARIS, Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2Sheffield Childrens Hospital, Sheffield, United Kingdom, 3Insigneo Institute for in silico Medicine, Sheffield, United Kingdom

Repeatability of inflation levels, and the imaging metrics derived from them, is important in hyperpolarized gas MRI, particularly when attempting to measure a response from interventions. This work presents same-session repeatability of 5 different inflation levels and their accuracy in comparison to plethysmography measures. Further the effect of inflation level on percent ventilated lung volume and coefficient of variation was investigated. The most repeatable lung volumes were total lung capacity, functional residual capacity plus 1 liter and residual volume. Percent ventilated lung volume was repeatable to within a maximum of 2% error.

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