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Abstract #2146

Optimization of free breathing radial DCE-MRI protocol for quantitative clinical evaluation of pleural malignancies

Thomas S.C. Ng1, Ravi T. Seethamraju2, and Ritu R. Gill1

1Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2Siemens Healthcare USA

Clinical diagnosis of pleural malignancies and evaluation of their treatment response to novel anti-angiogenic agents would benefit from quantitative clinical DCE-MRI. Implementation of robust DCE-MRI of the thorax is challenging given the presence of significant respiratory motion. We optimized a clinical DCE-MRI protocol based upon the Radial Stack of Stars acquisition scheme to obtain 3-dimensional motion insensitive DCE-MRI of pleural malignancies. When compared to other commonly used DCE-MRI protocols with cartisian acquisitions, our free breathing protocol demonstrated good SNR, minimal motion down to a spatial resolution of 2mm3.

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