Clinical diagnosis of pleural malignancies and evaluation of their treatment response to novel anti-angiogenic agents would benefit from quantitative clinical DCE-MRI. Implementation of robust DCE-MRI of the thorax is challenging given the presence of significant respiratory motion. We optimized a clinical DCE-MRI protocol based upon the Radial Stack of Stars acquisition scheme to obtain 3-dimensional motion insensitive DCE-MRI of pleural malignancies. When compared to other commonly used DCE-MRI protocols with cartisian acquisitions, our free breathing protocol demonstrated good SNR, minimal motion down to a spatial resolution of 2mm3.
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