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Abstract #2148

Reproducibility and Methodological Considerations for Dissolved-Phase 129Xe Spectroscopy in Patients with Idiopathic Pulmonary Fibrosis.

Neil J Stewart1, Nicholas D Weatherley1, Ho-Fung Chan1, Laura C Saunders1, Madhwesha Rao1, Guilhem J Collier1, Laurie Smith1, Matthew Austin2, Graham Norquay1, Stephen A Renshaw3, Stephen M Bianchi2, and Jim M Wild1

1Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals, Sheffield, United Kingdom, 3Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

The reproducibility of quantitative parameters of pulmonary gas-exchange function derived from 129Xe chemical shift saturation recovery (CSSR) and high-resolution spectroscopy (HRS) was evaluated in patients with idiopathic pulmonary fibrosis. Of the CSSR-derived parameters, surface-area-to-volume ratio was found to be most reproducible (intraclass correlation κ=0.756). Furthermore, the ratio of 129Xe signal in pulmonary red blood cells (RBC) to tissue/plasma (TP) from HRS exhibited good reproducibility (κ=0.760). The clinical interpretation of these results is discussed along with methodological considerations and their bearing on the future clinical potential of these techniques.

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