The reproducibility of quantitative parameters of pulmonary gas-exchange function derived from 129Xe chemical shift saturation recovery (CSSR) and high-resolution spectroscopy (HRS) was evaluated in patients with idiopathic pulmonary fibrosis. Of the CSSR-derived parameters, surface-area-to-volume ratio was found to be most reproducible (intraclass correlation κ=0.756). Furthermore, the ratio of 129Xe signal in pulmonary red blood cells (RBC) to tissue/plasma (TP) from HRS exhibited good reproducibility (κ=0.760). The clinical interpretation of these results is discussed along with methodological considerations and their bearing on the future clinical potential of these techniques.
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