Abstract #2152

Quantifying Changes in Time-Resolved Hyperpolarized 129Xe Spectroscopy among Healthy and IPF Subjects

Elianna A Bier^1,2, Scott H Robertson^1,2, Rohan S Virgincar^1,3, Mu He^1,4, Ziyi Wang^1,3, Geoff M Schrank¹, Rose Marie Smigla⁵, Craig Rackley⁶, H. Page McAdams⁶, and Bastiaan Driehuys^1,2,3,6

¹Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, ²Medical Physics Graduate Program, Duke University, Durham, NC, United States, ³Department of Biomedical Engineering, Duke University, Durham, NC, United States, ⁴Department of Electrical and Computer Engineering, Duke University, Durham, United States, ⁵Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Duke University Medical Center, Durham, NC, United States, ⁶Department of Radiology, Duke University Medical Center, Durham, NC, United States

The spectral parameters of ¹²⁹Xe in airspaces, interstitium and red blood cells (RBCs) are sensitive to disease. We sought to test how these parameters change during inhalation, breath-hold, and exhalation, and identify dynamic signatures that distinguish healthy subjects from patients with idiopathic pulmonary fibrosis (IPF). We find in all subjects that the RBC amplitude oscillates at the cardiac pulsation frequency. However, in IPF patients, this oscillation is also prominent in the chemical shift and phase of the RBC resonance. These dynamic metrics are potentially useful biomarkers for disease progression, as well as discriminating between different pathologies that impact gas exchange.

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