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Abstract #2151

Density-adapted UTE for SF6 visualisation in small animal lung imaging

Marta Tibiletti1, Armin M. Nagel2,3, and Volker Rasche4

1Core Facility Small Animal MRI, Ulm University, Ulm, Germany, 2Department of Diagnostic and Interventional Radiology, University Medical Center Ulm, Ulm, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4Internal Medicine II, University Hospital of Ulm, Ulm, Germany

Fluorinated gases as hexafluorane (SF6) may be used to visualize ventilations in lungs clinical and preclinical acquisitions. SF6 is characterized by T1 ~ T2* ~ 1 ms, therefore is best visualized with sequences allowing for short TR and TE, such as 3D UTE. SNR is generally limited by low spin density and low thermal polarization. In this work, we applied a density-adapted sampling scheme, previously developed for 23Na imaging, to the visualization of SF6 in phantom and in-vivo lung mice acquisitions. We verified that it increases image SNR and sharpness with respect to regular sampling without significant drawbacks.

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