Abstract #2165

Developmental assay with Magnetization Transfer Ratio in non-human primate

Marin Nishio^1,2, Yuji Komaki^2,3, Fumiko Seki^2,3,4, Junichi Hata^2,3,4, Akiko Uematsu^2,3,4, Ryutaro Yano^2,3, Ryosuke Ishihara^2,3, Erika Sasaki^2,3, Hideyuki Okano³, and Akira Furukawa¹

¹Tokyo Metropolitan University, Tokyo, Japan, ²Central Institute for Experimental Animals (CIEA), Kawasaki, Japan, ³School of Medicine Keio University, ⁴Brain Science Institute, RIKEN

MTR reflects the protein content such as myelin of brain. We examined the age-related MTR for common marmosets (1-18 months). Almost all regions of the brain have increased as T1 relaxation similar curve and the rate change of the MTR in each region was different. In voxel-wise analysis, MTR increase shows back-to-front maturation patterns in white matter. This pattern has observed in human studies. MTR can be a good marker to evaluate the normal brain development of common marmoset, and eventually a suitable parameter to assess brain developmental disorders for study, diagnosis, and treatments.

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