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Abstract #2165

Developmental assay with Magnetization Transfer Ratio in non-human primate

Marin Nishio1,2, Yuji Komaki2,3, Fumiko Seki2,3,4, Junichi Hata2,3,4, Akiko Uematsu2,3,4, Ryutaro Yano2,3, Ryosuke Ishihara2,3, Erika Sasaki2,3, Hideyuki Okano3, and Akira Furukawa1

1Tokyo Metropolitan University, Tokyo, Japan, 2Central Institute for Experimental Animals (CIEA), Kawasaki, Japan, 3School of Medicine Keio University, 4Brain Science Institute, RIKEN

MTR reflects the protein content such as myelin of brain. We examined the age-related MTR for common marmosets (1-18 months). Almost all regions of the brain have increased as T1 relaxation similar curve and the rate change of the MTR in each region was different. In voxel-wise analysis, MTR increase shows back-to-front maturation patterns in white matter. This pattern has observed in human studies. MTR can be a good marker to evaluate the normal brain development of common marmoset, and eventually a suitable parameter to assess brain developmental disorders for study, diagnosis, and treatments.

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