This study uses multi-parametric MRI measures to further our understanding on the pathophysiology of migraine in a novel preclinical model of medication overuse headache. Rats undergo sustained triptan exposure inducing cutaneous allodynia. Following drug exposure, we perform ASL, NMR, connectivity and evoked response BOLD fMRI to investigate sustained neuronal adaptations/changes. We investigate how drug overuse leads to latent sensitization to migraine triggers 20 days after exposure. We find significantly altered CBF levels in triptan treated animals. NMR reveals changes in GABA & Tau metabolite levels. fMRI shows changes in functional connectivity and activation of brain regions associated with pain pathways.
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