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Abstract #2166

The Pain of Pre-Clinical fMRI

Aneurin James Kennerley1, Devashish Das2, Fiona Boissonade3, and Milena De-Felice3

1Psychology, University of Sheffield, Sheffield, United Kingdom, 2Biological Services, University of Sheffield, Sheffield, United Kingdom, 3School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom

This study uses multi-parametric MRI measures to further our understanding on the pathophysiology of migraine in a novel preclinical model of medication overuse headache. Rats undergo sustained triptan exposure inducing cutaneous allodynia. Following drug exposure, we perform ASL, NMR, connectivity and evoked response BOLD fMRI to investigate sustained neuronal adaptations/changes. We investigate how drug overuse leads to latent sensitization to migraine triggers 20 days after exposure. We find significantly altered CBF levels in triptan treated animals. NMR reveals changes in GABA & Tau metabolite levels. fMRI shows changes in functional connectivity and activation of brain regions associated with pain pathways.

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