Abstract #2170

Characterization of a Murine High Altitude Exposure Model

Alexandru Korotcov^1,2, Asamoah Bosomtwi^1,2, Andrew Hoy^1,2, Daniel P. Perl^1,3, Nathan Cramer^1,4, Xiufen Xu⁴, Clarke Tankersley⁴, Zygmunt Galdzicki^1,4, and Bernard J. Dardzinski^1,2

¹Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States, ²Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD, United States, ³Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States, ⁴Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States

MRI is a useful technology for longitudinal assessments, which are critical for understanding vascular changes in the brain. Exposure to high-altitude (HA), hypoxic conditions, e.g. by military personnel, can result in physiological changes and ultimately degradation of neurobehavioral performance. We utilized in vivo MR imaging in mice to examine changes in brain vasculature, myelination and structure and to provide longitudinal insights into pathological changes caused by long-term exposure to HA. We observed changes in T2 that reflect edema/inflammation, fractional anisotropy changes that suggest changes in white matter myelination, and rCBF and VDi imaging indicating adaptations to HA conditions.

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