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Abstract #2171

Modulation of structural and functional networks in the ischemic mouse brain by stem cell therapy

Claudia Green1, Anuka Minassian1, Andreas Beyrau1, Stefanie Vogel1, Michael Diedenhofen1, Melanie Nelles1, Dirk Wiedermann1, and Mathias Hoehn1,2

1In-vivo NMR, MPI for Metabolism Research, Cologne, Germany, 2Dept. Radiology, Leiden University Medical Center, Leiden, Netherlands

In this study we combined rs-fMRI and diffusion MRI to assess the therapeutic capacity of cortically injected human neural stem cells in the mouse brain after stroke during 3 months. Seed-based analysis of diffusion anisotropy maps and functional connectivity were conducted interrelated with the main focus on the effect of stroke and treatment on the contralesional hemisphere. A delayed breakdown in functional network strength for the therapeutically treated group compared to a sham treated group is observed. However, diffusion anisotropy parameters stay stable with an increasing trend for the thalamus.

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