Abstract #2173

In vivo Magnetic Resonance Imaging of the Marmoset Spinal Cord at 7T

Jennifer A. Lefeuvre^1,2, Wen-Yang Chiang³, Nicholas J. Luciano¹, Cecil C. Yen³, Mathieu D. Santin², Stéphane Lehéricy², Steve Jacobson⁴, Afonso C. Silva³, Daniel S. Reich¹, and Pascal Sati¹

¹TNS/NIB/NINDS, National Institutes of Health, Bethesda, MD, United States, ²CENIR, UPMC-Inserm U1127, CNRS 7225, Institut Cerveau Moelle, Paris, France, ³CMS/LFMI/NINDS, National Institutes of Health, Bethesda, MD, United States, ⁴VIS/NIB/NINDS, National Institutes of Health, Bethesda, MD, United States

When induced to have experimental autoimmune encephalomyelitis (EAE), marmosets can suffer from motor and sensory deficits highly suggestive of lesions located in the spinal cord. In this study, we developed an in vivo spinal cord imaging protocol at 7T for marmosets, and were able to visualize gray and white matter as well as focal EAE lesions. Future work will focus on characterizing the spatiotemporal evolution of spinal cord EAE lesions over the disease course.

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