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Abstract #2177

Altered Cerebral Blood Flow and Cerebrovascular Function after Voluntary Exercise in Adult Mice

Lindsay S Cahill1, Jonathan Bishop1, Lisa M Gazdzinski1, Adrienne Dorr2, Bojana Stefanovic2,3, and John G Sled1,3

1Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada, 2Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

A longitudinal study employing continuous arterial spin labelling MRI with a hypercapnic challenge was used to examine changes in cerebral blood flow with physical exercise in healthy, adult mice. We found that exercise resulted in increases in the normocapnic and hypercapnic blood flow in the hippocampus and that these changes were positively correlated to the volume of the hippocampus following exercise. Interestingly, hypercapnic hippocampal blood flow prior to exercise was predictive of the distance subsequently run and exposure to this voluntary exercise regime was found to reduce these pre-existing blood flow differences.

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