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Abstract #2178

Altered nigrostriatal system in the MPTP Squirrel Monkey model revealed by diffusion MRI at 11.7T.

Alexandra Petiet1,2, Mathieu Santin1,2, Elodie Laffrat2, Romain Valabrègue1,2, Thomas Samoyeau2, Stéphane Hunot2, and Stéphane Lehéricy1,2

1Center for Neuroimaging Research, Brain and Spine Institute, Paris, France, 2CNRS UMR 7225/INSERM 1127/UPMC UM75, Brain and Spine Institute, Paris, France

Parkinson’s disease (PD) is characterized by neurodegeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNc). The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin can induce Parkinson syndrome in primate models. We evaluated the nigrostriatal (NS) pathway degeneration in MPTP Squirrel monkeys using diffusion MRI. The results showed significantly increased fractional anisotropy in all NS regions of the MPTP group (SN, caudate and putamen regions). Axial diffusivity also significantly increased in the SN and caudate regions, while radial diffusivities did not show any differences, except a significantly decreased λ3 in the putamen. Those results should help develop preclinical evaluation of PD therapeutics.

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