Abstract #2183

Enhanced neuroplasticity by physical exercise for hypoxic ischemic injured rat brain monitored by BOLD-fMRI

Sun Young Chae^1,2, Geun Ho Im^3,4, Moon-Sun Jang^3,4, Won-Beom Jung^1,5, and Jung Hee Lee^1,2,3,5

¹Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, ²Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea, Republic of, ³Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, ⁴Center for Molecular and Cellular Imaging, Samsung Biomedical Research Institute, Seoul, Korea, Republic of, ⁵Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Physical exercise is known to boost the spontaneous recovery, but the exact mechanism for exercise induced recovery after brain injury is not clearly known. In this study, we show enhanced neuroplasticity with physical exercise on the intact side as well as the damaged side for the HI injured rat brain by calculating the brain activation maps from BOLD-fMRI: Increased inter-hemispheric transfer and intra-hemispheric extension of activated areas were observed with physical exercise covering the widespread sensory-motor related areas in the contralesional hemisphere.

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