Abstract #2184

Quantification of vascular water transport using time-resolved pulsed arterial spin labelling MRI at 9.4 T

Adnan Bibic^1,2, Thea Sordia¹, Erik Henningsson³, Linda Knutsson^1,4, Freddy Ståhlberg², and Ronnie Wirestam¹

¹Medical Radiation Physics, Lund University, Lund, Sweden, ²Lund University Bioimaging Centre, Lund University, Lund, Sweden, ³Centre for Mathematical Sciences, Lund University, Lund, Sweden, ⁴Department of Radiology (Adjunct), Johns Hopkins School of Medicine, Baltimore, MD, United States

In this study, an improved quantification approach for measuring ASL transit-time parameters is proposed. The concept is based on multi-TI ASL measurements, where the dynamics of the inverted spins are described by the Fokker-Planck equation. The random forces in this equation are assumed to occur due to pseudo-diffusion in the capillaries and subsequent filtration through the blood brain barrier (BBB). The obtained time for the intravascular water to distribute from arteries through the capillary bed and into the parenchyma can, for example, be related to the capillary function as well as to the integrity of the BBB.

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