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Abstract #2184

Quantification of vascular water transport using time-resolved pulsed arterial spin labelling MRI at 9.4 T

Adnan Bibic1,2, Thea Sordia1, Erik Henningsson3, Linda Knutsson1,4, Freddy Ståhlberg2, and Ronnie Wirestam1

1Medical Radiation Physics, Lund University, Lund, Sweden, 2Lund University Bioimaging Centre, Lund University, Lund, Sweden, 3Centre for Mathematical Sciences, Lund University, Lund, Sweden, 4Department of Radiology (Adjunct), Johns Hopkins School of Medicine, Baltimore, MD, United States

In this study, an improved quantification approach for measuring ASL transit-time parameters is proposed. The concept is based on multi-TI ASL measurements, where the dynamics of the inverted spins are described by the Fokker-Planck equation. The random forces in this equation are assumed to occur due to pseudo-diffusion in the capillaries and subsequent filtration through the blood brain barrier (BBB). The obtained time for the intravascular water to distribute from arteries through the capillary bed and into the parenchyma can, for example, be related to the capillary function as well as to the integrity of the BBB.

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