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Abstract #2185

Phenotyping of transgenic Huntington’s disease minipigs by MR spectroscopy

Nina Nagelmann1, Frauke Freisfeld2, Robin Schubert 2, Sarah Schramke2, Verena Schuldenzucker 2, Lorena Rieke2, Tamara Matheis2, Harald Kugel1, Ralf Reilmann1,2, and Cornelius Faber1

1Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany, 2George-Huntington-Institute, Muenster, Germany

Huntington’s Disease (HD) is a fatal neurodegenerative disorder, caused by a single genetic mutation, and characterized by deficits in motor coordination, behavior and cognition. A transgenic minipig model of HD has been established. Here, we employ single voxel MRS at 3 T to acquire metabolic profiles from the brain of this model over four years. We show that seven metabolite combinations can be quantified in adolescent and adult minipigs. Pathologic alterations in the phenotype were not observed at the age studied.

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