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Abstract #2190

Optical control of blood flow in naive animals

Ravi L Rungta1, Bruno-FĂ©lix Osmanski1, Davide Boido1, Mickael Tanter2, and Serge Charpak1

1U1128, INSERM, Paris, France, 2U979, INSERM, Paris, France

Optogenetics is increasingly used to map brain activation using techniques that rely upon functional hyperemia, for example opto-fMRI. Here we demonstrate that light stimulation protocols similar to those commonly used in opto-fMRI increase blood flow in mice that do not express light sensitive proteins. These results impose careful consideration on the use of photo-activation in studies involving blood flow regulation and suggest light could be used as a technical or therapeutic tool to locally increase blood flow in a controlled fashion.

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