We assessed whether ultrasmall superparamagnetic iron oxide (USPIO) phagocytosed by microglia contribute to tumor enhancement in MR imaging of N-ethyl-N-nitrosourea (ENU)-induced endogenous rat brain gliomas by comparing MR images with the corresponding histological sections. USPIO-enhanced MR imaging may provide pure vascular bed images in the early phase within 6 hours after intravenous administration of USPIO agent because it was histologically proved that the administrated agent remained within intravascular space. In the late phase at 63-66 hours after the administration, USPIO-enhanced Gradient-Recalled-Echo T2-weighted images may depict the distribution of microglia that were magnetically labeled by USPIO agent.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords