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Abstract #2189

USPIO-enhanced magnetic resonance imaging of N-ethyl-N-nitrosourea- induced endogenous rat gliomas: contribution of USPIO-related iron-loaded microglia to signal changes

Ryuta ITO1, Atsuko YAMAMOTO2, Shigehiro MORIKAWA3, and Kiyoshi MURATA1

1Radiology, Shiga University of Medical Science, Otsu, Japan, 2Radiology, Kohka public hospital, Kohka, Japan, 3Shiga University of Medical Science, Otsu, Japan

We assessed whether ultrasmall superparamagnetic iron oxide (USPIO) phagocytosed by microglia contribute to tumor enhancement in MR imaging of N-ethyl-N-nitrosourea (ENU)-induced endogenous rat brain gliomas by comparing MR images with the corresponding histological sections. USPIO-enhanced MR imaging may provide pure vascular bed images in the early phase within 6 hours after intravenous administration of USPIO agent because it was histologically proved that the administrated agent remained within intravascular space. In the late phase at 63-66 hours after the administration, USPIO-enhanced Gradient-Recalled-Echo T2-weighted images may depict the distribution of microglia that were magnetically labeled by USPIO agent.

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