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Abstract #2193

Dynamic Longitudinal DTI Metric Changes of Hippocampus in Developing Non-Human Primate

Akiko Uematsu1,2,3, Junichi Hata1,3, Yuji Komaki3, Fumiko Seki1,2,3, Chihoko Yamada3, Erika Sasaki1,2,3, and Hideyuki Okano1,2

1Keio University School of Medicine, Tokyo, Japan, 2Riken, Wako, Japan, 3Central Institute for Experimental Animals, Kawasaki, Japan

We investigated typical hippocampal development of a non-human primate model, common marmoset, using longitudinal DTI metrics data. Our findings showed dynamical non-linear developmental changes of hippocampal volume, MD and RD especially in its anterior part and suggested its neural turning point would be at puberty. These findings would give insights of disorder and disease of onset specific to developmental period.

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