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Abstract #2194

Dynamic uptake of manganese in the developing mouse brain

Holly E Holmes1, Orlando Aristizabal1, Oghale Obaro-Best1,2, Estefania Gallego1, Hari Rallapalli1, and Daniel H Turnbull1

1Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, NY, United States, 2Department of Chemistry, SUNY Plattsburgh, Plattsburgh, NY, United States

Manganese-enhanced MRI (MEMRI) is a powerful technique for imaging rodent neuroanatomy. We investigated differences in the uptake of paramagnetic manganese ions (Mn2+) in the mouse brain at two postnatal days: P7 and P21. We observed higher uptake of Mn2+ in all neuroanatomical regions-of-interest (ROIs) at P7; this increased uptake was reflected in the shorter T1 times at P7 relative to P21. We also observed faster clearance of Mn2+ within the ventricles at P21. Our findings highlight the spatiotemporal differences in Mn2+ uptake and may be useful when planning MEMRI studies in the developing mouse brain.

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