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Abstract #2195

Morphological growth patterns in common marmoset developing brain

Fumiko Seki1,2,3, Yuji Komaki1,2, Junichi Hata1,2,3, Akiko Uematsu1,2,3, Erika Sasaki1,2, Keigo Hikishima4, and Hideyuki Okano1,3

1Department of Physiology, Keio University, Tokyo, Japan, 2Central Institute of Experimental Animals, 3Laboratory for Marmoset Neural Architecture, RIKEN BSI, 4Okinawa Institute of Science and Technology Graduate University

The postnatal brain development at the macroscale in common marmoset has been studied based on the volume measurement, as is not well-studied despite its importance. Maximizing the feature that it takes only 2 years to reach adulthood, the longitudinal MRI was conducted for 23 subjects. The volume of gray matter was inverted U curve trajectories, while increase of white matter became stable around 12 months old. Developmental patterns of regions in cerebral cortex were similar to gray matter but different in developmental timing. The study can demonstrate overall growth patterns were similar to patterns previously reported in humans and other monkeys.

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