Abstract #2197

Fast macromolecular proton fraction mapping validated in the murine model of cuprizone induced demyelination

Marina Khodanovich¹, Irina Sorokina², Valentina Glazacheva¹, Andrey Akulov³, Alexandr Romashchenko³, Tatyana Tolstikova⁴, Lilia Mustafina⁵, and Vasily Yarnykh⁶

¹Laboratory of Neurobiology, Tomsk State University, Tomsk, Russian Federation, ²N.N.Vorozhtsov Novosibirsk Institute of Organic Chemistry, Russian Federation, ³Institute of Cytology and Genetics, Novosibirsk, Russian Federation, ⁴N.N.Vorozhtsov Novosibirsk Institute of Organic Chemistry, Novosibirsk, Russian Federation, ⁵Siberian State Medical University, Tomsk, Russian Federation, ⁶Department of Radiology, University of Washington, Seattle, WA, United States

A recently developed quantitative MRI method, fast macromolecular proton fraction mapping (MPF) has shown a promise as a biomarker of myelin in human and animal studies with a particular advantage of sensitivity to grey matter (GM) demyelination. This study aimed to histologically validate the capability of MPF mapping using the cuprizone demyelination model. MPF strongly correlated with quantitative histology in all animals (r=0.95, p<0.001) as well as in treatment and control groups taken separately (r=0.97, p=0.001 and r=0.95, p=0.003, respectively). Close agreement between MPF and histology suggests that fast MPF mapping enables robust and accurate quantitative non-invasive assessment of demyelination.

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