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Abstract #2198

Changes of metabolite levels with low SNR in brain tumours measured by hybrid FET PET and 3D MRSI

Jörg Mauler1, Karl-Josef Langen1,2, Andrew A. Maudsley3, Omid Nikoubashman4, Christian Filss1,2, Gabriele Stoffels1, and N. Jon Shah1,5

1Institute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, Jülich, Germany, 2Department of Nuclear Medicine, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 3Miller School of Medicine, University of Miami, Miami, FL, United States, 4Department of Neuroradiology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 5Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany

The specificity of MR based diagnosis of gliomas may be improved by O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake measured with PET and metabolite changes obtained from simultaneously acquired volumetric MR spectroscopic imaging. In order to cope with low SNR of the metabolites, the MR spectra of 25 patients were subject-specifically averaged within the tumour borders transferred from FET PET and compared to non-affected white matter of the contra lateral side. Strongest signal drops were found for GLU (0.58±0.43, WHO II) and NAA (0.33±0.13, WHO II-IV), strongest increase for CHO/NAA (3.9±2.4). The metabolite changes showed no dependency on tumour grade.

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