Abstract #2198

Changes of metabolite levels with low SNR in brain tumours measured by hybrid FET PET and 3D MRSI

Jörg Mauler¹, Karl-Josef Langen^1,2, Andrew A. Maudsley³, Omid Nikoubashman⁴, Christian Filss^1,2, Gabriele Stoffels¹, and N. Jon Shah^1,5

¹Institute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, Jülich, Germany, ²Department of Nuclear Medicine, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, ³Miller School of Medicine, University of Miami, Miami, FL, United States, ⁴Department of Neuroradiology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, ⁵Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany

The specificity of MR based diagnosis of gliomas may be improved by O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake measured with PET and metabolite changes obtained from simultaneously acquired volumetric MR spectroscopic imaging. In order to cope with low SNR of the metabolites, the MR spectra of 25 patients were subject-specifically averaged within the tumour borders transferred from FET PET and compared to non-affected white matter of the contra lateral side. Strongest signal drops were found for GLU (0.58±0.43, WHO II) and NAA (0.33±0.13, WHO II-IV), strongest increase for CHO/NAA (3.9±2.4). The metabolite changes showed no dependency on tumour grade.

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