Abstract #2201

Anticorrelated networks dysfunction in patients with brain tumor in frontal lobe

Chen Niu¹, Xiao Ling¹, Pan Lin², Kun Zhang³, Xin Liu⁴, Hao Song², Liping Guo¹, Wenfei Li¹, Maode Wang⁵, and Ming Zhang¹

¹Department of Medical Imaging, The First Affiliated Hospital of Xi'An Jiaotong University, Xi'An, People's Republic of China, ²Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi’an Jiaotong University, ³Department of Electronics Engineering, Northwestern Polytechnical University, ⁴Technical University Munich, ⁵Department of neurosurgery, The First Affiliated Hospital of Xi'An Jiaotong University, Xi'An, People's Republic of China

The aim of this study is to evaluate whether the lesion in frontal lobe would cause the change of brain positive and negative network interaction, thereby affecting cognitive function. We employed a MSIT to compare the task-positive and DMN changes of brain tumor patients and the healthy controls. Our results indicated the interaction relationship between the task-positive and DMN in patients with brain tumor in the frontal lobe was significantly decreased. We suggest that reduced anti-correlation between DMN and task-positive networks in patients with brain tumor may be caused by dysfunctional DMN, thus affecting the cognitive function of patient.

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