Abstract #2211

Influence of leakage correction on DSC-based CBV values acquired without and with prebolus in human high-grade glioma

Dennis M. Hedderich¹, Anne Kluge¹, Thomas Pyka², Claus Zimmer¹, Jan S. Kirschke¹, Benedikt Wiestler¹, and Christine Preibisch¹

¹Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany, ²Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

Aim of this study was to investigate the influence of leakage correction methods on dynamic susceptibility contrast (DSC)-based measures of cerebral blood volume (CBV), using patient data acquired with and without pre-bolus. Two post-processing techniques were compared with respect to normalized CBV (nCBV) in contrast enhancing tumor tissue. Generally, CBV increased or decreased after leakage correction for data acquired without or with prebolus, respectively. The best agreement between corrected nCBV values, obtained in the same patients without and with prebolus, respectively, was obtained for a reference curve-based correction approach.

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