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Abstract #2212

Multimodal study of treated brain tumours combining non-Gaussian diffusion MRI and 18F-FET-PET

Farida Grinberg1,2, Ganna Blazhenets1,3, Francesco D’Amore1, Ezequiel Farrher1, Christian Filβ1, Karl-Josef Langen1, and N. Jon Shah1,2,4

1Institute of Neuroscience and Medicine 4, Research Centre Jülich, Jülich, Germany, 2Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany, 3Institute of Nuclear Physics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany, 4JARA - BRAIN - Translational Medicine, RWTH Aachen University, Germany

PET using O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) provides important diagnostic information in brain tumours. In this work, we report a novel combined application of PET imaging and MRI with advanced non-Gaussian diffusion MRI methods including diffusion kurtosis imaging and gamma-distribution function imaging. This is the first multimodal study combining metabolic information from FET-PET and microstructural information gained from non-Gaussian diffusion models. The main goal was to investigate the advantages of such a combined application in tumour assessment and to compare the sensitivity of various non-Gaussian diffusion metrics to the underlying microstructural tissue properties.

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