Abstract #2212

Multimodal study of treated brain tumours combining non-Gaussian diffusion MRI and 18F-FET-PET

Farida Grinberg^1,2, Ganna Blazhenets^1,3, Francesco D’Amore¹, Ezequiel Farrher¹, Christian Filβ¹, Karl-Josef Langen¹, and N. Jon Shah^1,2,4

¹Institute of Neuroscience and Medicine 4, Research Centre Jülich, Jülich, Germany, ²Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany, ³Institute of Nuclear Physics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany, ⁴JARA - BRAIN - Translational Medicine, RWTH Aachen University, Germany

PET using O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) provides important diagnostic information in brain tumours. In this work, we report a novel combined application of PET imaging and MRI with advanced non-Gaussian diffusion MRI methods including diffusion kurtosis imaging and gamma-distribution function imaging. This is the first multimodal study combining metabolic information from FET-PET and microstructural information gained from non-Gaussian diffusion models. The main goal was to investigate the advantages of such a combined application in tumour assessment and to compare the sensitivity of various non-Gaussian diffusion metrics to the underlying microstructural tissue properties.

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