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Abstract #2213

Relating the Evolution of RT-Induced Vascular Injury to surrounding white matter microstructure in Adult Glioma Patients

Melanie A Morrison1, Andrew Leynes1, Angela Jakary1, Prasanna Parvathaneni1, Peder Larson1, and Janine Lupo1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

In the treatment of gliomas, radiation therapy (RT) is associated with long-term effects including vascular injury in the form of cerebral microbleeds (CMBs), and changes in the white matter and thickness of cortex. Ultra high-field MRI techniques were used to characterize RT-induced changes across serial scans in support of ongoing investigations of the role of anti-angiogenic therapies in minimizing treatment effects. Steady increases in the number of CMBs was observed decades post-RT. CMB foci were characterized by increased isotropic diffusion when compared to surrounding white matter, which showed signs of degradation in as few as two months between serial scans.

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