Abstract #2216

Effect of Lesion Contaminated Nuisance Regressors on Resting-state fMRI Connectivity in Patients with Brain Tumors

Ai-Ling Hsu^1,2, Ping Hou¹, Sujit S Prabhu³, Rivka R Colen⁴, Ashok J Kumar⁴, Jason Michael Johnson⁴, Donald F Schomer⁴, Jyh-Horng Chen², and Ho-Ling Liu¹

¹Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ³Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, ⁴Departments of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center

Resting-state fMRI has been shown its potential for pre-surgical mapping. The potential confounds are commonly removed by regressing out the averaged fluctuation over masks of white matter and cerebrospinal fluid. However, for the patients with brain lesions, these masks may be contaminated by lesions. In current study, we generated masks by segmentation and template approaches. Although these masks were contaminated by lesion in most of our patients, no significant difference in FC was found due to this effect, which might be related to small samples. Comparing to segmentation approach, more variable results were observed when masks obtained by template approach.

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