In this study, a new approach for assessing distribution of bloodstream inflow and outflow type based on the three-time point (3TP) method was used to semi-quantitative analysis of the microcirculation characteristics in whole pituitary adenoma by dynamic contrast-enhanced MRI (DCE-MRI). The volume percentage of persistently enhancing type of time-intensity curve (TIC) in adenoma was higher than normal region. Meanwhile, adenomas with hyperprolactinemia were shown a significant decrease of volume percentage in speed up the downhill type when compared with the adenoma without hyperprolactinemia. This method could identify the different distribution of vascularity between normal pituitary and subtype of adenoma.
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