Preoperative prediction of genotypic classification with MRI is useful because IDH mutation and 1p/19q codeletion status are important prognostic and predictive factors in lower-grade gliomas (WHO grade II and III). In this study we found that various preoperative imaging features including lobar/nonlobar or central location, enhancement characteristics, tumor margin, diffusion characteristics, ependymal/cortical involvement were different between IDH-wildtype and IDH-mutant group. Therefore preoperative MRI may be helpful to predict IDH mutation status in lower-grade gliomas.
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