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Abstract #2226

Molecular imaging of pediatric cerebellar tumors using endogenous protein-based amide proton transfer MR imaging at 3 Tesla

Hong Zhang1, Yi Zhang2, Xiaolu Tang1, Huiying Kang1, Di Hu1, Jinyuan Zhou2, and Yun Peng1

1Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, People's Republic of China, 2Department of Radiology, Johns Hopkins University, MD, United States

Amide proton transfer (APT)-MRI is a chemical exchange saturation transfer (CEST) based approach in which the amide protons of endogenous proteins and peptides are irradiated to accomplish detection using the water signal. In this study, the APT approach was incorporated with standard brain MRI sequences and applied to children with cerebellar tumors at 3T. The initial results show that APT imaging can enhance the noninvasive identification of tissue heterogeneity and may be a biomarker of tumor grade in pediatric cerebellar tumors.

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