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Abstract #2227

Comparison of native longitudinal relaxation rate, apparent diffusion coefficient, and extravascular extracellular volume fraction in vestibular schwannoma in type 2 neurofibromatosis before and after antiangiogenic therapy

Ka-Loh Li1, Ibrahim Djoukhadar1, Sha Zhao1, Natale Quartuccio1, Amy Watkins1, Xiaoping Zhu1, and Alan Jackson1

1Division of Informatics, Imaging and Data Sciences, The University of Manchester, Manchester, United Kingdom

The relationship between three functional parameters related to cell density, ADC, R1N, and ve, were examined in 12 patients with vestibular schwannomas pre- and post- anti-angiogenic therapy. 3D maps of R1N obtained with variable flip angle images, and ve derived from DCE-MRI were compared to 3D maps of ADC. The tumor mean values of ADC, R1N and ve showed correlation to each other before bevacizumab treatment. This correlation was lost after three-months of treatment. Both R1N and ADC displayed power in prediction of treatment. R1N showed more sensitive to anti-angiogenic therapy induced changes in VS than ADC or ve.

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