Abstract #2227

Comparison of native longitudinal relaxation rate, apparent diffusion coefficient, and extravascular extracellular volume fraction in vestibular schwannoma in type 2 neuroﬁbromatosis before and after antiangiogenic therapy

Ka-Loh Li¹, Ibrahim Djoukhadar¹, Sha Zhao¹, Natale Quartuccio¹, Amy Watkins¹, Xiaoping Zhu¹, and Alan Jackson¹

¹Division of Informatics, Imaging and Data Sciences, The University of Manchester, Manchester, United Kingdom

The relationship between three functional parameters related to cell density, ADC, R1_N, and v_e, were examined in 12 patients with vestibular schwannomas pre- and post- anti-angiogenic therapy. 3D maps of R1_N obtained with variable flip angle images, and v_e derived from DCE-MRI were compared to 3D maps of ADC. The tumor mean values of ADC, R1_N and v_e showed correlation to each other before bevacizumab treatment. This correlation was lost after three-months of treatment. Both R1_N and ADC displayed power in prediction of treatment. R1_N showed more sensitive to anti-angiogenic therapy induced changes in VS than ADC or ve.

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