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Abstract #2228

Metabolic and functional MR imaging probe early response in glioblastoma patients treated with combination antiangiogenic-chemoradiation therapy

Ovidiu C Andronesi1, Morteza Esmaeili, Ronald Borra, Kyrre Emblem, Elizabeth Gerstner, Marco Pinho, Scott Plotkin, Andrew Chi, April Eichler, Jorg Dietrich, Percy Ivy, Patrick Wen, Dan Duda, Rakesh Jain, Bruce Rosen, Gregory Sorensen, and Tracy Batchelor

1Radiology, Massachusetts General Hospital, Boston, MA, United States

Precise assessment of treatment response in glioblastoma during combined antiangiogenic and chemoradiation remains a challenge. In particular, early detection of treatment response by standard anatomical imaging is confounded by pseudo-response or pseudo-progression. Metabolic changes probed by MRSI are more specific for tumor physiology and less confounded by changes in blood-brain barrier permeability.

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