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Abstract #2229

Assessment of therapeutic response in glioma with spillover-, MT- and T1-corrected amide proton transfer MR imaging

Jing Zhao1, Yiying Zhao2, Yinsheng Chen2, Zhongping Chen2, and Yin Wu1

1Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People's Republic of China, 2Department of Neurosurgery, Cancer Center, Sun Yat-Sen University, Guangzhou, People's Republic of China

Amide proton transfer (APT) MR imaging has proved to be capable of detecting/grading brain tumors as well as assessing treatment response. Routinely used magnetization transfer (MT) asymmetry is contaminated with MT, nuclear overhauser effect (NOE) and T1 relaxation time of water. In this study, the dominant contributors of direct water saturation and MT to Z-spectrum were estimated from a sum of two Lorentzian functions, and APT was corrected with T1 scale and inverse Z-spectrum analysis. Results showed that the corrected APT can reliably depict glioma heterogeneity post-treatment, in accordance with H & E histological observations.

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