We applied graph theoretical network analysis on multi-echo resting-state fMRI data to examine whether healthy people with subclinical psychotic-like experiences (schizotypy) show abnormal functional brain topology compared to similar subjects without such experiences. While we did not observe significant between-group differences in any connectivity measure (Local and global efficiency, Modularity, and Small-worldness), within the schizotypy group we found that modularity and small-worldness were directly related to the severity of subclinical psychotic-like experiences. This demonstrates the feasibility of applying graph theory on multi-echo rs-fMRI in individuals with vulnerability for psychotic disorders and encourages the application of these methods in psychosis research.
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