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Abstract #2246

Gray matter reduction is associated with poor treatment response in patients with schizophrenia: A voxel-based morphometry study with a strict control of multiple clinical variables

Jing-Ying Huang1, Chih-Min Liu2,3, Tzung-Jeng Hwang2,3, Yu-Jen Chen1, Yung-Chin Hsu1, Hai-Gwo Hwu2,3, and Wen-Yih Isaac Tseng1,3,4,5

1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 2Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, 3Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan, 4Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, 5Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

To investigate whether remitted and non-remitted patients with schizophrenia had distinctly different gray matter volumes, we used voxel-based morphometry (VBM) to analyze group difference by controlling all possible clinical variables. As compared with remitted patients, the non-remitted patients showed 10 brain areas with significantly decreased gray matter volume. Our results imply that remitted and non-remitted patients might have distinct patterns of gray matter reduction, and the characteristics of gray matter change might represent the structural correlate of treatment response in patients with schizophrenia.

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