Abstract #2247

Repeated Binge Alcohol Intoxication Leads to Lower Choline-Containing Compound Signals in Rat Brain: An In Vivo Marker of Alcohol-Induced Neurobiological Abnormalities

Dong-Hoon Lee^1,2, Do-Wan Lee^3,4,5, Ji-Yeon Park⁶, Hae-Jin Park⁷, Kyu-Ho Song^4,5, Yong Hyun Chung², Dong-Cheol Woo⁸, and Bo-Young Choe^4,5

¹Brain and Mind Centre, University of Sydney, Sydney, Australia, ²Department of Radiological Science, Yonsei University, Wonju, Korea, Republic of, ³Ewha Brain Institute, Ewha Womans University, Seoul, Korea, Republic of, ⁴Department of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Korea, Republic of, ⁵Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul, Korea, Republic of, ⁶Department of Radiation Oncology, University of Florida, Gainesville, FL, United States, ⁷Department of Radiation Oncology, Ajou University School of Medicine, Suwon, Korea, Republic of, ⁸MR Core Laboratory, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of

Alcohol is the most commonly abused intoxicating substance among young and middle-aged adults, and ranks highly as a cause of disability and mortality. A pattern of heavy consumption, called binge drinking, leads to various psychiatric disorders. We used in vivo proton magnetic resonance spectroscopy (¹H MRS) to quantitatively assess neurochemical responses in hippocampus in a rat model of repeated-binge alcohol (RBA) intoxication. We determined that choline-containing compound, gamma-aminobutyric acid, and total N-acetyl-aspartate (tNAA: N-acetyl-aspartate + N-acetyl-aspartyl-glutamate) signals were highly sensitive to binge alcohol intoxication, which provides insights into neurochemical alterations associated with alcohol abuse.

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