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Abstract #2248

Eigenvector centrality mapping evaluating disease progression in Parkinson disease :a longitudinal study

qiaoling zeng1, xiaojun guan1, min xuan1, quanquan gu1, xiaojun xu1, and minming zhang1

12nd Affiliated Hospital, Zhejiang University School of Medicine, hangzhou, People's Republic of China

Studied longitudinally 21 PD patients using Eigenvector centrality mapping,discovered significantly decreased EC values in right postcentral gyrus, and increased EC values in right cerebellum, right supplementary motor area (right SMA) as compared to B group. right postcentral gyrus in F group is negativelycorrelatedwithhoehn and yahr staging( HY) stage (r =-0.48, p < 0.05). Variation of EC values (F group-B group) in right cerebellum is positively correlated with changeofUPDRS-III scores. The current study demonstrated that deterioration and compensation exists through different circuit along with PD progression.

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