Schizophrenia is a mental disorder with structural and functional alterations that are not completely comprehended. We used a pseudo-continuous ASL protocol to investigate changes in resting CBF in schizophrenic patients. In addition, quantitative T1 and Gray Matter Volume (GMV) were assessed. Decreased CBF, GMV, and T1 values were observed in schizophrenic patients compared with healthy controls in several brain regions consistent with patients’ symptoms, such as deficits in planning solving and organizing thoughts. Therefore, motor, sensorial and cognitive impairments observed in schizophrenia may be related to CBF deficits and structural alterations in localized brain regions.