Meeting Banner
Abstract #2253

Association between Major Depressive Disorder and the Functional Val158Met Polymorphism in Catechol-O-Methyltransferase as Assessed by Diffusion MRI

Chuan Huang1,2,3, Karl Spuhler3, Christine DeLorenzo1,3, and Ramin Parsey1

1Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States, 2Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 3Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States

Major Depressive Disorder is a debilitating illness that impacts 1 in 6 people in the United States during their lifetime. Particularly when monoamine levels are low, depression is associated with reduced volume in the front-limbic-striatum emotional processing network. Catechol-O-Methyltransferase (COMT) is responsible for most dopamine degradation in the frontal cortex. Guided by past literature, we examined the effect of COMT genotype on white matter integrity in the amygdala, hippocampus and parahippocampus in depressed patients along with healthy controls. Our results suggest the existence of sex-genotype interaction which is clinically relevant for women suffering from depression.

This abstract and the presentation materials are available to members only; a login is required.

Join Here