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Abstract #2254

Structural alterations in major depressive disorder and bipolar disorder-I: A meta-analysis of voxel-based morphometry study

Qiang Luo1, Ziqi Chen1, Xinyu Hu1, Xiaoqi Huang1, and Qiyong Gong1

1Huaxi MR Research Center (HMRRC), Chengdu, People's Republic of China

We used the SDM software to detect the similarities and differences of gray matter (GM) volume between MDD and BD, and found the significant decreases of GM in the bilateral insula and left inferior frontal gyrus (LIFG) characterized both MDD and BD-I, which may be related with the clinical symptoms including using few words and exhibiting poor choices of conversation topics during depressive state in both two affective disorders. AND the MDD patients had significantly lower GM volumes in the right superior temporal gyrus and right amygdala in comparison with BD-I patients, which indicated that reduced GM volume in the right angular gyrus specifically characterizes BD-I which may contribute to the manic symptom.

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