By using the VBM method，We found Neuronal damage may occurred in the early stage of the PTSD patients and dysfunction in orbitofrontal cortex, insula cortex which involving in the limbic system, and the precuneus involving in the DMN might play a critical role in pathophysiology of PTSD. By using the SPS rat model to mimic the PTSD disease, we also found iron accumulation in the prefrontal cortex, striatum, hippocampus in the SPS rat model. This study indicated that iron may be involved in the pathology of PTSD, and could be nominated as a novel molecule involved in the pathology of PTSD and provide a potential target for therapeutic intervention of PTSD.
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