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Abstract #2258

Gulf War Illness Patients Exhibit Impaired Connectivity in Multiple Brain Function Networks Consistent with Chronic Multi-Symptom Illness: A Resting State fMRI Study

Kaundinya Gopinath1, Binod Thapa-Chetry2, Lou Ouyang2, Lisa Krishnamurthy2, Venkatagiri Krishnamurthy1, Aman Goyal2, Parina Gandhi2, Yan Fang2, Unal Sakoglu3, and Robert Haley2

1Department of Radiology & Imaging Sciences, Emory University, Atlanta, GA, United States, 2University of Texas Southwestern Medical Center, Dallas, TX, United States, 3University of Houston Clear-Lake, Houston, TX, United States

Around 200,000 veterans (up to 32% of those deployed) of the 1991 Gulf War (GW) suffer from GW illness (GWI), which is characterized by multiple deficits in cognitive, emotion, somatosensory and pain domains. In this study we examined 22 GWI patients and 30 age-matched controls with resting state fMRI (rsFMRI) in order to map impairments in brain function networks in GWI with graph theory based advanced network analysis methods. Results show widespread impairments in functional connectivity of cognition, affective, somatosensory and pain processing brain function networks in GWI consistent with multi-symptom nature of the illness.

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