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Abstract #2277

Study of functional connectivity of default mode network and frontoparietal network in neuromyelitis optica

Han Yongliang1, Li Yongmei1, LUO Qi1, ZENG Chun1, WANG Jingjie1, DU Silin1, ZHANG Xiaohui1, and GUO Youyou1

1Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China

Neuromyelitis optica (NMO) is an inflammatory, demyelinating syndrome of the central nervous system characterized by severe attacks of optic neuritis and myelitis, but investigators in several studies observed abnormalities in deep gray matter. Functional MRI (fMRI) has the potential to further understanding of the neuropathologic mechanisms of NMO. In the present study, our aim was to investigate patients with NMO-related alterations of brain functional connectivity(FC) in resting state in default mode network (DMN) and frontoparietal network(FPN) using independent component analysis(ICA) and their correlations with clinical features.

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