Abstract #2278

Reorganisation of cerebellar and dentate nucleus activity in multiple sclerosis subjects performing a complex visuomotor task: An event-related fMRI study

Adnan A.S. Alahmadi^1,2, Rebecca S. Samson¹, Matteo Pardini^1,3, Egidio D'Angelo^4,5, Karl J. Friston⁶, Ahmed T. Toosy¹, and Claudia AM Gandini Wheeler-Kingshott^1,4,7

¹UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, ²Department of Diagnostic Radiology, Faculty of Applied Medical Science, KAU, Jeddah, Saudi Arabia, ³Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa, Genoa, Italy, ⁴Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁵Brain Connectivity Centre, C. Mondino National Neurological Institute, Pavia, Italy, ⁶Wellcome Centre for Imaging Neuroscience, University College London, London, United Kingdom, ⁷Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy

This study investigates the response to different grip force levels in the cerebellum and its dentate nucleus in MS. We found that cerebellar responses were functionally parcellated; with linear effects in the anterior cerebellum and complex nonlinear responses in the posterior cerebellum. This behaviour is consistent with healthy subjects (nonlinear responses in bilateral lobules V-VI and ipsilateral VIII), although MS subjects additionally show a strong linear response in lobule I-IV and nonlinear responses primarily localised in lobules V-VI. In the dentate nucleus, the motor portion in MS was silent as compared to the healthy subjects.

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